Homeostatic responses to amino acid insufficiency

被引：7

作者：

Anthony, Tracy G. ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Nutr Sci, New Brunswick, NJ 08901 USA

来源：

ANIMAL NUTRITION | 2015年 / 1卷 / 03期

基金：

美国国家卫生研究院;

关键词：

mTOR; GCN2; Integrated stress response; Asparaginase; Eukaryotic initiation factor 2; Activating transcription factor 4;

D O I：

10.1016/j.aninu.2015.10.001

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 [畜牧学];

摘要：

This article provides a brief overview describing how two key signaling pathways, namely the integrated stress response and the mammalian target of rapamycin complex 1, work together to facilitate cellular adaptation to dietary amino acid insufficiency. A deeper understanding of these mechanisms is leading to identification of novel targets which aid in disease treatments, improve stress recovery and increase health span through slowed aging and enhanced metabolic fitness. (C) 2015 Chinese Association of Animal Science and Veterinary Medicine. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

引用

页码：135 / 137

页数：3

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