MANNICH AND ESCHWEILER-CLARKE REACTION OF 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINES . STUDIES ON SYNTHESES OF HETEROCYCLIC COMPOUNDS .318.

被引：12

作者：

KAMETANI, T

NOGUCHI, I

SAITO, K

机构：

[1] Pharmaceutical Institute, Tohoku University and Hitachi Chemical Co, Ltd., Sendai

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1969年 / 6卷 / 06期

关键词：

D O I：

10.1002/jhet.5570060616

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Modified Mannich reactions of a number of 1‐benzyl‐1,2,3,4‐tetrahydroisoquinolines (Ia‐Ie) were attempted to afford the corresponding protoberberine derivatives (IIa‐IIe) in good yield. Treatment of both If and Ig with formalin under a variety of Mannich or Eschweiler‐Clarke conditions did not give the expected protoberberine derivatives IIf and IIg, but afforded the N‐methyl derivatives (VIIa) and (VIIb), respectively. Copyright © 1969 Journal of Heterocyclic Chemistry

引用

页码：869 / &

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