HERPETIC KERATOCONJUNCTIVITIS - THERAPY WITH SYNTHETIC DOUBLE-STRANDED RNA

被引：148

作者：

PARK, JH

BARON, S

机构：

[1] Branch of Isotope Geology, U.S. Geological Survey, Denver

[2] Office of Anthropology, Smithsonian Institution, Washington

[3] Department of Opthalmology, New York Medical College

[4] Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD

来源：

SCIENCE | 1968年 / 162卷 / 3855期

关键词：

D O I：

10.1126/science.162.3855.811

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A study was undertaken in rabbits to determine how late in the course of keratoconjunctivitis caused by herpes simplex recovery could be effected by an inducer of interferon. Interferon was induced by means of synthetic double-stranded RNA copolymer formed with polynosinic acid : polycytidilic acid RNA. Therapy promotes recovery from severe and fully established keratoconjunctivitis for which treatment was begun as late as 3 days after virus inoculation. No drug toxicity was observed in the therapeutic dose range. These findings further support the proposed role of the interferon mechanism in the natural recovery of already established viral infection. They also suggest the usefulness of interferon inducers in viral infections of man.

引用

页码：811 / &

共 26 条

[1] INTERFERON [J].

BARON, S ;

LEVY, HB .

ANNUAL REVIEW OF MICROBIOLOGY, 1966, 20 :291-+

[2]

BARON S, 1966, J IMMUNOL, V96, P12

[3]

BARON S, 1966, INTERFERONS, P268

[4]

BARON S, 1967, MODERN TRENDS MEDICA, P77

[5]

BARON S, PERSONAL COMMUNICATI

[6]

BILLIAU A, 1968, PERSONAL COMMUNICATI

[7]

BORECKY L, 1967, ACTA VIROL, V11, P264

[8]

BUCKLER CE, 1968, PERSONAL COMMUNICATI

[9]

CANTELL K, 1960, LANCET, V2, P682

[10]

DILUZIO NR, 1967, RETICULOENDOTHELI ED, P315

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