LONG INSERTIONS WITHIN TELOMERES CONTRIBUTE TO CHROMOSOME SIZE POLYMORPHISM IN PLASMODIUM-BERGHEI

被引：31

作者：

PACE, T

PONZI, M

DORE, E

JANSE, C

MONS, B

FRONTALI, C

机构：

[1] IST SUPER SANITA,CELLULAR BIOL LAB,I-00161 ROME,ITALY

[2] UNIV LEIDEN,PARASITOL LAB,LEIDEN,NETHERLANDS

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 12期

关键词：

D O I：

10.1128/MCB.10.12.6759

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During prolonged in vivo mitotic multiplication of a Plasmodium berghei ANKA clone (8417HP), parasites that contained an enlarged version of chromosome 4 were observed. Restriction mapping and hybridization results demonstrated that the extra DNA present in the enlarged chromosomes consists of 2.3-kb tandem repeats, known to be normally located in subtelomeric position at several chromosomal ends but absent in the original chromosome. The inserted 2.3-kb units appeared to interrupt one of the original telomeres and to create an internal (~1-kb-long) telomeric sequence.

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页码：6759 / 6764

页数：6

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