PROTON RELAXATION ENHANCEMENT IN EXPERIMENTAL BRAIN-TUMORS - INVIVO NMR-STUDY OF MANGANESE(III)TPPS IN RAT-BRAIN GLIOMAS

被引：26

作者：

BOCKHORST, K ^{[1
]}

HOHNBERLAGE, M ^{[1
]}

KOCHER, M ^{[1
]}

HOSSMANN, KA ^{[1
]}

机构：

[1] MAX PLANCK INST NEUROL FORSCH EXPTL NEUROL ABT,GLEUELER STR 50,W-5000 COLOGNE 47,GERMANY

来源：

MAGNETIC RESONANCE IMAGING | 1990年 / 8卷 / 04期

关键词：

Histology; MnTPPS; Rat brain glioma; Relaxation enhancement;

D O I：

10.1016/0730-725X(90)90058-A

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The effect of manganese(III)tetraphenylporphine sulfonate (MnTPPS) on the relaxation enhancement of NMR images (MRI) was studied in experimental brain tumors in rats. Brains were inoculated with the glioma cell line F98 12 to 19 days before the NMR experiment, and the effect of MnTPPS (0.25 mmol/kg body weight) was investigated 2 and 4 days after intraperitoneal injection. After MnTPPS addition tumors could be clearly distinguished by the brightness from the surrounding brain whereas they were barely visible without contrast enhancement. At SE time of 25 msec and TR time of 3500 msec the ratio of magnetization values of tumor versus normal grey matter increased from 0.98 ± 0.08 to 1.24 ± 0.09 (means ± SD). When TR was shortened to 1100 msec contrast enhancement further increased to 1.77 ± 0.25. These results demonstrate for the first time that MnTPPS is an efficient agent for contrast enhancement of brain tumors. © 1990.

引用

页码：499 / 504

页数：6

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