DIFFERENCES IN SERUM BILE-ACID COMPOSITION BETWEEN UNOPERATED CIRRHOTIC PATIENTS AND PATIENTS WITH PORTACAVAL OR MESOCAVAL SHUNT

Serum bile acids were determined in 13 cirrhotic patients with portocaval shunt and in 15 with mesocaval shunt. Twenty nonshunted cirrhotics were used as controls. Serum bile acid levels were higher in portocaval (26.7 ± 14.3 μg/ml) than in mesocaval shunt patients (16.9 ± 8.1 μg/ml) and controls (14.1 ± 11.5 μg/ml). The cholic/chenodeoxycholic ratio was lower after portocaval shunt than after mesocaval shunt (0.36 ± 0.15 and 0.63 ± 0.26, respectively). It is hypothesized that these findings may be consistent with a larger hepatic blood flow present in mesocaval shunted patients and with chenodeoxycholic absorption in the upper small intestine.