VITAMIN-E DERIVATIVES AS NEW POTENT INHIBITORS OF MICROSOMAL LIPID-PEROXIDATION

被引：21

作者：

BATTIONI, JP ^{[1
]}

FONTECAVE, M ^{[1
]}

JAOUEN, M ^{[1
]}

MANSUY, D ^{[1
]}

机构：

[1] UNIV JOSEPH FOURIER,LEDSS,CNRS,URA 332,F-38041 GRENOBLE,FRANCE

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 174卷 / 03期

关键词：

D O I：

10.1016/0006-291X(91)91534-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several synthetic Vitamin E derivatives are strong inhibitors of lipid peroxidation induced in rat liver microsomes either chemically by ferrous ions and ascorbate or enzymatically by NADPH and carbon tetrachloride. The relative activities of these inhibitors are consistent with their intrinsic antioxidant properties, as peroxyl radicals scavengers. Among them, a 3,4-dihydro-6-hydroxy-2H-1-naphtopyran with IC50 around 0.08 μM is one of the most potent yet known inhibitor of lipid peroxidation. © 1991.

引用

页码：1103 / 1108

页数：6

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