PRESYNAPTIC ENHANCEMENT OF SYNAPTIC TRANSMISSION IN HIPPOCAMPAL CELL-CULTURES BY PHORBOL ESTERS

被引：51

作者：

FINCH, DM

JACKSON, MB

机构：

[1] UNIV CALIF LOS ANGELES,DEPT BIOL,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,DEPT NEUROL,LOS ANGELES,CA 90024

来源：

BRAIN RESEARCH | 1990年 / 518卷 / 1-2期

关键词：

Glutamate; Long-term potentiation; Miniature excitatory synaptic current; Protein kinase C;

D O I：

10.1016/0006-8993(90)90979-L

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The calcium-diacylglycerol activated protein kinase (C kinase) plays an important role in synaptic plasticity, and possibly in long-term potentiation (LTP). We have found that phorbol esters, which activate this protein kinase, increase the frequency of miniature excitatory postsynaptic currents (mEPCs) in hippocampal cell cultures. An analysis of distributions of these miniature synaptic currents shows that amplitudes, and thus postsynaptic function, are not influenced by phorbol esters. Synaptic transmission is therefore enhanced by phorbol esters at a presynaptic locus. The method of analysis employed here is applicable to a broad range of situations involving modification of synaptic transmission in the mammalian central nervous system. © 1990.

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页码：269 / 273

页数：5

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