10-MEMBERED RING ENEDIYNES WITH REMARKABLE CHEMICAL AND BIOLOGICAL PROFILES

被引：52

作者：

NICOLAOU, KC

SORENSEN, EJ

DISCORDIA, R

HWANG, CK

MINTO, RE

BHARUCHA, KN

BERGMAN, RG

机构：

[1] UNIV CALIF SAN DIEGO, DEPT CHEM, LA JOLLA, CA 92093 USA

[2] UNIV CALIF BERKELEY, DEPT CHEM, BERKELEY, CA 94720 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1992年 / 31卷 / 08期

关键词：

D O I：

10.1002/anie.199210441

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The large effects of minimal structural variations are demonstrated by enediynes 1. At 50 °C the cis isomer cyclizes much faster (t1/2 = 4 h) than the trans isomer (t1/2 = 22 h). The carbonate derivative of trans‐l is stable even for several hours at 100 °C. The exploration of the chemistry of cyclic enediynes is prompted by their DNA‐cleaving properties. (Figure Presented.) Copyright © 1992 by VCH Verlagsgesellschaft mbH, Germany

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页码：1044 / 1046

页数：3

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