INTRATHECAL BACLOFEN - DOES TOLERANCE OCCUR

被引：44

作者：

AKMAN, MN ^{[1
]}

LOUBSER, PG ^{[1
]}

DONOVAN, WH ^{[1
]}

ONEILL, ME ^{[1
]}

ROSSI, CD ^{[1
]}

机构：

[1] INST REHABIL & RES,1333 MOURSUND AVE,HOUSTON,TX 77030

来源：

PARAPLEGIA | 1993年 / 31卷 / 08期

关键词：

INTRATHECAL BACLOFEN; SPASTICITY; SPINAL CORD INJURY; TOLERANCE;

D O I：

10.1038/sc.1993.84

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Concern over the development of tolerance in patients on continuous intrathecal baclofen therapy has arisen as this new form of treatment for spasticity has gained wider use. We have studied time-dose relationships in 18 spinal cord injured patients who have undergone intrathecal baclofen infusion pump implantation since February 1988 in our facility. Our data show that there was a significant increase in baclofen dosage needed to control spasticity during the first 12 months post implantation. After 12 months, however, no significant change in dosage requirement was detected. In addition, there was no significant difference between completely and incompletely spinal cord injured patients with regard to both the initial dose and the tolerance trend.

引用

页码：516 / 520

页数：5

共 15 条

[1] Penn R.D., Kroin J.S., Long-term intrathecal baclofen infusion for treatment of spasticity, J Neurosurg, 66, 2, pp. 181-185, (1987)
[2] Muller H., Dralle J.D., Borner U., Hoffmann O., The effect of intrathecal baclofen onelectrical muscle activity in spasticity, J Neural, 234, 5, pp. 348-352, (1987)
[3] Zierski J., Muller H., Dralle D., Wurdinger T., Implanted pump systems for treatment of spasticity, Acta Neurachir Suppl (Wien), 43, pp. 94-99, (1988)
[4] Parke B., Penn R.D., Savoy S.M., Carcos D., Functional outcome after delivery of intrathecal baclofen, Arch Phys Med Rehabil, 70, 1, pp. 30-32, (1989)
[5] Penn R.D., Savoy S.M., Corcos D., Gottlieb L.M., Et al., Intrathecal baclofen for severespinal spasticity, N Engl J Med, 320, 23, pp. 1517-1521, (1989)
[6] Ochs G., Struppler A., Meyerson B., Linderoth B., Gybels J., Gardner B.P., Pet Al T., Intrathecalbaclofen for long-term treatment of spasticity: A multi-center study, J Neurol Neurosurg Psychiatry, 52, pp. 933-939, (1989)
[7] Broseta J., Garcia-March G., Sanchez-Ledesma M.J., Anaya J., Silva I., Chronic intrathecal baclofenadministration in severe spasticity, Stereotact Fund Neurosurg, 54, pp. 147-153, (1990)
[8] Lazorthes Y., Sallerin-Caute B., Verdie J.C., Bastide R., Carillo J.P., Chronic intrathecal baclofenadministration for control of severe spasticity, J Neurasurg, 72, pp. 393-402, (1990)
[9] Loubser P.G., Narayan R.K., Sandin K.J., Donovan W.H., Russel K.D., Continuous infusion of intrathecalbaclofen: Long-term effects on spasticity in spinal cord injury, Paraplegia, 29, 1, pp. 48-64, (1991)
[10] Sahuquillo J., Muxi T., Noguer M., Jodar R., Closa C., Rubio E., Et al., Intraspinal baclofen in thetreatment of severe spasticity and spasms, Acta Neurochir (Wien), 110, pp. 166-173, (1991)

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