STUDIES DIRECTED TOWARD THE SYNTHESIS OF THE RUTAMYCINS - ASSEMBLAGE OF THE POLYPROPIONATE REGION OF RUTAMYCIN-B

被引：25

作者：

EVANS, DA

NG, HP

机构：

[1] Department of Chemistry, Harvard University, Cambridge

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 14期

关键词：

D O I：

10.1016/S0040-4039(00)77580-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric synthesis of the polypropionate segment of rutamycin B is reported. In this convergent synthesis the construction of the C1-C8 arid C9-C17 Subunits and their union through a double stereodifferentiating aldol fragment coupling am described. The stereoselectivity of this coupling reaction critically depends on both the configuration and choice of protecting group for the C-9 oxygen.

引用

页码：2229 / 2232

页数：4

共 20 条

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