PROGNOSTIC FACTORS IN HUMAN PRIMARY BREAST-CANCER - COMPARISON OF C-MYC AND HER2/NEU AMPLIFICATION

被引:42
作者
BERNS, EMJJ [1 ]
FOEKENS, JA [1 ]
VANPUTTEN, WLJ [1 ]
VANSTAVEREN, IL [1 ]
PORTENGEN, H [1 ]
DEKONING, WCH [1 ]
KLIJN, JGM [1 ]
机构
[1] DR DANIEL DEN HOED CANC CTR, DEPT MED ONCOL, DIV ENDOCRINE ONCOL, POB 5201, 3008 AE ROTTERDAM, NETHERLANDS
关键词
D O I
10.1016/0960-0760(92)90182-I
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Amplification of oncogenes in primary tumours may have prognostic and/or therapeutic significance for patients with breast cancer. We have studied HER2/neu and c-myc amplification together with steroid receptors in human primary breast tumours and related the outcome with (relapse-free) survival. A strong inverse correlation was found between HER2/neu amplification and the presence of oestrogen and progesterone receptors. Actuarial 5-years survival showed that breast cancer patients with c-myc amplification in their primary tumours experience a shorter relapse-free survival, especially in node-negative and in receptor-positive tumours, whereas HER2/neu amplification may be of prognostic value for overall survival in receptor-negative tumours. Overall, in our hands, c-myc amplification appeared to be a more potent prognosticator than HER2/neu amplification in human primary breast cancer.
引用
收藏
页码:13 / 19
页数:7
相关论文
共 76 条
[1]  
ADNANE J, 1989, ONCOGENE, V4, P1389
[2]   PRESENCE OF 2 MEMBERS OF C-ERBA RECEPTOR GENE FAMILY (C-ERBA-BETA AND C-ERBA2) IN SMALLEST REGION OF SOMATIC HOMOZYGOSITY ON CHROMOSOME 3P21-P25 IN HUMAN-BREAST CARCINOMA [J].
ALI, IU ;
LIDEREAU, R ;
CALLAHAN, R .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1989, 81 (23) :1815-1820
[3]   REDUCTION TO HOMOZYGOSITY OF GENES ON CHROMOSOME-11 IN HUMAN-BREAST NEOPLASIA [J].
ALI, IU ;
LIDEREAU, R ;
THEILLET, C ;
CALLAHAN, R .
SCIENCE, 1987, 238 (4824) :185-188
[4]  
ALI IU, 1989, ONCOGENE, V4, P89
[5]  
ALI IU, 1988, BREAST CANCER CELLUL, P25
[6]   BREAST-CANCER - ONCOGENES AND SUPPRESSOR GENES [J].
ANDERSON, E ;
HOWELL, T .
ANNALS OF ONCOLOGY, 1990, 1 (04) :242-243
[7]   THE NEU ONCOGENE ENCODES AN EPIDERMAL GROWTH-FACTOR RECEPTOR-RELATED PROTEIN [J].
BARGMANN, CI ;
HUNG, MC ;
WEINBERG, RA .
NATURE, 1986, 319 (6050) :226-230
[8]  
BERGER MS, 1988, CANCER RES, V48, P1238
[9]  
BERNS EMJ, 1991, 4TH INT C HORM CANC
[10]  
BERNS EMJ, IN PRESS P INT S CLI