LIPASE CATALYSIS IN ORGANIC-SOLVENTS - APPLICATION TO THE SYNTHESIS OF (R)-ATENOLOL AND (S)-ATENOLOL

被引：53

作者：

BEVINAKATTI, HS

BANERJI, AA

机构：

[1] Alchemie Research Centre, ICI India Limited site, Thane-400601, Maharashtra, Thane-Belapur Road

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 22期

关键词：

D O I：

10.1021/jo00048a040

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of (R)- and (S)-atenolol (1) was achieved in five steps starting from p-hydroxyphenylacetic acid. Lipase from Pseudomonas cepacia showed excellent selectivity toward kinetic resolution of key intermediates 1-[p-[(butoxycarbonyl)methyl]phenoxy]-3-chloropropan-2-ol (9) and its O-acetyl ester, 1-[p-[(butoxycarbonyl)methyl]phenoxy]-2-acetoxy-3-chloropropane (10).

引用

页码：6003 / 6005

页数：3

共 25 条

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