APPROACHES TO SAR IN CARCINOGENESIS AND MUTAGENESIS - PREDICTION OF CARCINOGENICITY/MUTAGENICITY USING MULTI-CASE

被引：125

作者：

KLOPMAN, G ^{[1
]}

ROSENKRANZ, HS ^{[1
]}

机构：

[1] UNIV PITTSBURGH,GRAD SCH PUBL HLTH,DEPT ENVIRONM & OCCUPAT HLTH,PITTSBURGH,PA 15238

来源：

MUTATION RESEARCH | 1994年 / 305卷 / 01期

关键词：

SAR; PREDICTION TO; PREDICTION OF CARCINOGENICITY/MUTAGENICITY; MULTI-CASE;

D O I：

10.1016/0027-5107(94)90124-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The assumptions and considerations underlying the use of structure-activity studies in the field of genotoxicity are discussed and reviewed. The MULTI-CASE program, recently introduced as a second generation CASE program is described and its special features highlighted. Some of the problems relevant to the use of structure-activity tools are also discussed. A list of these problems is as follows: Problems with non-congeneric data bases, Problems with expert systems, Problems with the size of the data bases, Problems with ''structural alerts'', Problems with QSAR, Problems with Metabolic transformations, and Problems with short-term assays.

引用

页码：33 / 46

页数：14

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