DOSAGE-DEPENDENT MODIFIERS OF WHITE ALLELES IN DROSOPHILA-MELANOGASTER

被引：30

作者：

SABL, JF ^{[1
]}

BIRCHLER, JA ^{[1
]}

机构：

[1] HARVARD UNIV,BIOL LABS,CAMBRIDGE,MA 02138

来源：

GENETICAL RESEARCH | 1993年 / 62卷 / 01期

关键词：

D O I：

10.1017/S0016672300031517

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

As part of a study to identify dosage-sensitive modifiers of the white eye colour locus and the retrotransposon, copia, a segmental aneuploid screen was conducted. It surveys the autosomal complement of the genome for dosage dependent modifiers of white, including ones effective upon retrotransposon insertion-induced alleles. Several regions were found which, when present as a segmental trisomy, affected one or more of the alleles tested in a strong and consistent fashion. Two of these regions have been identified as containing previously described modifiers, Darkener-of-apricot and Inverse regulator-a. The remainder identify new white allele modifiers. Selected segmental monosomics were also tested where possible for regions exhibiting a trisomic effect. At least three regions were found to have a dosage-dependent effect in one, two and three copies.

引用

页码：15 / 22

页数：8

共 31 条

[1] EVIDENCE THAT WHITE-BLOOD IS A NOVEL TYPE OF TEMPERATURE-SENSITIVE MUTATION RESULTING FROM TEMPERATURE-DEPENDENT EFFECTS OF A TRANSPOSON INSERTION ON FORMATION OF WHITE TRANSCRIPTS [J].