ADH EVOLUTION AND THE PHYLOGENETIC FOOTPRINT

被引：11

作者：

DORIT, RL ^{[1
]}

AYALA, FJ ^{[1
]}

机构：

[1] HARVARD UNIV,DEPT ORGANISM & EVOLUTIONARY BIOL,CAMBRIDGE,MA 02138

来源：

JOURNAL OF MOLECULAR EVOLUTION | 1995年 / 40卷 / 06期

关键词：

ALCOHOL DEHYDROGENASE; PHYLOGENETIC FOOTPRINT; DROSOPHILIDAE; PROTEIN EVOLUTION;

D O I：

10.1007/BF00160514

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The evolution of any given protein reflects the interplay between proximal selective forces involving the conservation of protein structure and function and more general populational factors that shape the action and efficiency of natural selection. In an attempt to address that interplay, we have analyzed patterns of amino acid replacement within a well-conserved molecule, alcohol dehydrogenase (ADH), in the Drosophilidae. A sliding window, moved along the protein sequence in order to quantify the extent of change at each amino acid position, reveals heterogeneous amounts of replacement across the molecule when all ADH sequences are analyzed simultaneously. Surprisingly, the replacement profile for ADH differs significantly in the melanogaster, mulleri, and Hawaiian subgroups, reflecting the imprint of the differing evolutionary histories of each of these assemblages on the evolution of this conservative molecule.

引用

页码：658 / 662

页数：5

共 34 条

[1] NUCLEOTIDE-SEQUENCE OF THE ADH GENE OF DROSOPHILA-LEBANONENSIS [J].

ALABAT, R ;

GONZALEZDUARTE, R .

NUCLEIC ACIDS RESEARCH, 1990, 18 (22) :6706-6706

[2]

ANDERSON CL, 1993, MOL BIOL EVOL, V10, P605

[3]

ASHBURNER M, 1984, NATURE, V309, P425

[4]

ATKINSON PW, 1988, GENETICS, V120, P713

[5]

AYALA FJ, 1995, UNPUB DISTRIBUTION R

[6] ALCOHOL-DEHYDROGENASE GENE OF DROSOPHILA-MELANOGASTER - RELATIONSHIP OF INTERVENING SEQUENCES TO FUNCTIONAL DOMAINS IN THE PROTEIN [J].

BENYAJATI, C ;

PLACE, AR ;

POWERS, DA ;

SOFER, W .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (05) :2717-2721

[7]

COYNE JA, 1986, EVOLUTION, V40, P673, DOI 10.1111/j.1558-5646.1986.tb00530.x

[8]

DESALLE R, 1988, EVOLUTION, V42, P1076, DOI 10.1111/j.1558-5646.1988.tb02525.x

[9] STRUCTURE AND TRANSCRIPTION OF THE DROSOPHILA-MULLERI ALCOHOL-DEHYDROGENASE GENES [J].

FISCHER, JA ;

MANIATIS, T .

NUCLEIC ACIDS RESEARCH, 1985, 13 (19) :6899-6917

[10] THE SUPEROXIDE-DISMUTASE MOLECULAR CLOCK REVISITED [J].

FITCH, WM ;

AYALA, FJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (15) :6802-6807

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