EFFECT OF H-1 AND H-2 HISTAMINE-ANTAGONISTS ON SYMPTOMATIC DERMOGRAPHISM

被引：56

作者：

MATTHEWS, CNA

BOSS, JM

WARIN, RP

STORARI, F

机构：

[1] SMITH KLINE & FRENCH LABS,RES INST,WELWYN GARDEN CITY,ENGLAND

[2] BRISTOL ROYAL INFIRM,DEPT DERMATOL,BRISTOL BS2 8HW,AVON,ENGLAND

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1979年 / 101卷 / 01期

关键词：

D O I：

10.1111/j.1365-2133.1979.tb15293.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

In ten patients suffering from symptomatic dermographism the combined administration of chlor‐phemiramine + cimetidine produced a greater reduction in the weal and flare response provoked by a standardized scratch than the administration of chlorpheniramine alone. There was a statistically significant improvement in the overall assessment of the patient's skin condition with the combined administration of chlorpheniramine + cimetidine. Chlorpheniramine given alone produced no significant benefit whilst cimetidine alone produced a marked exacerbation in itching in nearly half the patients who initially entered the study and was sufficient to require with‐drawal. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：57 / 61

页数：5