ANTIMICROBIAL INTERFERENCE WITH BACTERIAL MECHANISMS OF PATHOGENICITY - EFFECT OF SUB-MIC AZITHROMYCIN ON GONOCOCCAL PILIATION AND ATTACHMENT TO HUMAN EPITHELIAL-CELLS

被引：18

作者：

GORBY, GL

MCGEE, ZA

机构：

[1] UNIV UTAH,SCH MED,CTR INFECT DIS DIAGNOST MICROBIOL & IMMUNOL,SALT LAKE CITY,UT 84132

[2] CREIGHTON UNIV,SCH MED,DEPT MED MICROBIOL,OMAHA,NE 68131

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 12期

关键词：

D O I：

10.1128/AAC.34.12.2445

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The effects of subinhibitory concentrations of azithromycin (CP-62,993) on the piliation and attachment properties of Neisseria gonorrhoeae were examined. Subinhibitory concentrations of azithromycin significantly reduced the percentage of gonococci that expressed assembled pili on their surfaces by decreasing pilin subunit synthesis and substantially decreased gonococcal adherence to human mucosal cells.

引用

页码：2445 / 2448

页数：4

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