HOW MHC CLASS-II MOLECULES WORK - PEPTIDE-DEPENDENT COMPLETION OF PROTEIN FOLDING

被引：71

作者：

SADEGHNASSERI, S

GERMAIN, RN

机构：

[1] Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda

来源：

IMMUNOLOGY TODAY | 1992年 / 13卷 / 02期

关键词：

D O I：

10.1016/0167-5699(92)90131-P

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It is now clear that peptides play a key role in stabilizing the structure of MHC class II molecules. Here, Scheherazade Sadegh-Nasseri and Ron Germain propose that newly synthesized MHC class II, and indeed class I, molecules behave like partially folded proteins, with peptides acting as a surrogate portion of the MHC polypeptide structure that is necessary for completion of conformational maturation.

引用

页码：43 / 46

页数：4

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