EFFECTS OF HUMAN INSULIN-LIKE GROWTH FACTOR-I ON RELEASE OF GROWTH-HORMONE BY RAINBOW-TROUT (ONCORHYNCHUS-MYKISS) PITUITARY-CELLS

被引：95

作者：

PEREZSANCHEZ, J ^{[1
]}

WEIL, C ^{[1
]}

LEBAIL, PY ^{[1
]}

机构：

[1] INRA,PHYSIOL POISSONS LAB,F-35042 RENNES,FRANCE

来源：

JOURNAL OF EXPERIMENTAL ZOOLOGY | 1992年 / 262卷 / 03期

关键词：

D O I：

10.1002/jez.1402620308

中图分类号：

Q95 [动物学];

学科分类号：

071002 ;

摘要：

A recombinant human IGF-I (rhIGF-I) was applied to primary cultures of rainbow trout pituitary cells. In wells containing 3 x 10(4) and 6 x 10(4) cells/well, rhIGF-I inhibited basal GH release both in short (6 h) and long (12 and 24 h) exposures. The decline in GH release was dose-dependent over the range of 0.01 and 100 mM. The combination of rhIGF-I and low concentrations of synthetic somatostatin 14 (SRIF) enhanced the inhibitory effect of rhIGF-I in an additive manner. Any appreciable effect of rhIGF-I on PRL release was not evidenced. To our knowledge, this report demonstrates for the first time the participation of IGFs on the inhibitory component of fish GH regulation.

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页码：287 / 290

页数：4

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