PEDUNCULAR RUBRAL TREMOR AND DOPAMINERGIC DENERVATION - A PET STUDY

被引：134

作者：

REMY, P

DERECONDO, A

DEFER, G

LOCH, C

AMARENCO, P

PANTEBORDENEUVE, V

DAOCASTELLANA, MH

BENDRIEM, B

CROUZEL, C

CLANET, M

RONDOT, P

SAMSON, Y

机构：

[1] CHU ST ANTOINE,SERV NEUROL,PARIS,FRANCE

[2] CHU HENRI MONDOR,SERV NEUROL,F-94010 CRETEIL,FRANCE

[3] CHU BICETRE,SERV NEUROL,LE KREMLIN BICETR,FRANCE

[4] CHU PURPAN,SERV NEUROL,TOULOUSE,FRANCE

[5] CH ST ANNE,SERV NEUROL,PARIS,FRANCE

来源：

NEUROLOGY | 1995年 / 45卷 / 03期

关键词：

D O I：

10.1212/WNL.45.3.472

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Lesions causing so-called rubral tremors frequently involve the substantia nigra or the nigrostriatal fibers, suggesting dopaminergic denervation as possibly contributory. We examined this hypothesis using PET and [F-18]-fluorodopa in six patients with a contralateral tremor following a peduncular lesion. The denervation revealed by PET was even more marked than in severe parkinsonian patients. All patients show ed partial to complete improvement with levodopa therapy. PET evaluation of D-2-receptors with [Br-76]bromolisuride showed no asymmetry of the D-2 binding despite the important asymmetry of F-18-fluorodopa uptake. Our results indicate an important involvement of the nigral dopaminergic system in peduncular tremors that appears to be independent of postsynaptic dopamine receptors.

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页码：472 / 477

页数：6

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