FEEDBACK OF THE DROSOPHILA PERIOD GENE-PRODUCT ON CIRCADIAN CYCLING OF ITS MESSENGER-RNA LEVELS

被引：866

作者：

HARDIN, PE ^{[1
]}

HALL, JC ^{[1
]}

ROSBASH, M ^{[1
]}

机构：

[1] BRANDEIS UNIV,DEPT BIOL,WALTHAM,MA 02254

来源：

NATURE | 1990年 / 343卷 / 6258期

关键词：

D O I：

10.1038/343536a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mutations in the period (per) gene of Drosophila melanogaster affect both circadian and ultradian rhythms. Levels of per gene product undergo circadian oscillation, and it is now shown that there is an underlying oscillation in the level of per RNA. The observations indicate that the cycling of per-encoded protein could result from per RNA cycling, and that there is a feedback loop through which the activity of per-encoded protein causes cycling of its own RNA. © 1990 Nature Publishing Group.

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页码：536 / 540

页数：5

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