NEW TECHNETIUM-99M-EDTA COMPLEX PRODUCTION TECHNIQUE FOR RENAL STUDIES

被引：4

作者：

AGHA, NH

ALHILLI, AM

HASSEN, HA

机构：

[1] Radioisotope Production Department, Nuclear Research Centre, Baghdad, P.O. Box 765, Tuwaitha

来源：

INTERNATIONAL JOURNAL OF APPLIED RADIATION AND ISOTOPES | 1979年 / 30卷 / 06期

关键词：

D O I：

10.1016/0020-708X(79)90019-X

中图分类号：

TL [原子能技术]; O571 [原子核物理学];

学科分类号：

0827 ; 082701 ;

摘要：

In the preparation of 99mTc-labelled radiopharmaceuticals the use of tin chloride for the generation of 99mTc in the required valance state is very well known. The fact that the redox potential of Cu1+/Cu2+ system is of the same order as that of Sn2+/Sn4+ lead us to investigate in detail the use of cuprous ions as an alternative reducing agent for tin. An efficient and simple method using the induced cuprous ions in the preparation of 99mTcCuEDTA complex within a few minutes has been described. Gel chromatography column scanning technique (GCS) has been found to be a very useful tool for studying the fraction of 99mTc-pertechnetate, 99mTc-chelate and the reduced hydrolyzed-99mTc in the preparation. Biokinetic studies in rats showed a long-term retention of the complex in kidneys. © 1979.

引用

页码：353 / 358

页数：6

共 7 条

[1]

AGHA N, 1977, NUKLEARMED, V16, P30

[2]

Bianchi C, 1972, Prog Nucl Med, V2, P21

[3]

FLEAY RF, 1968, AUSTR RADIOLOGY, V12, P256

[4] COMPLEX FORMATION OF TECHNETIUM WITH CHELATE FORMING LIGANDS .2. [J].

GORSKI, B ;

KOCH, H .

JOURNAL OF INORGANIC & NUCLEAR CHEMISTRY, 1970, 32 (12) :3831-&

[5]

PERSSON RBR, 1973, RADIOPHARMACEUTICALS, V1, P169

[6]

PERSSON RBR, 1975, 1974 P INT S RAD ATL, P228

[7] REDUCTION OF PERTECHNETATE-99 BY STANNOUS CHLORIDE .1. STOICHIOMETRY OF REACTION IN HCL, IN A CITRATE BUFFER AND IN A DTPA BUFFER [J].

STEIGMAN, J ;

MEINKEN, G ;

RICHARDS, P .

INTERNATIONAL JOURNAL OF APPLIED RADIATION AND ISOTOPES, 1975, 26 (10) :601-609

← 1 →