SIGN INVERSION MECHANISM FOR ENZYMATIC SUPERCOILING OF DNA

被引：276

作者：

BROWN, PO

COZZARELLI, NR

机构：

[1] UNIV CHICAGO, DEPT THEORET BIOL, CHICAGO, IL 60637 USA

[2] UNIV CHICAGO, DEPT BIOPHYS, CHICAGO, IL 60637 USA

[3] UNIV CHICAGO, COMM GENET, CHICAGO, IL 60637 USA

来源：

SCIENCE | 1979年 / 206卷 / 4422期

关键词：

D O I：

10.1126/science.227059

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Both the introduction and the removal of supertwists by DNA gyrase change the linking number of DNA in steps of two. This surprising finding provides strong evidence that gyrase acts by a mechanism, called sign inversion, whereby a positive supercoil is directly inverted into a negative one via a transient doublestrand break. Copyright © 1979 AAAS.

引用

页码：1081 / 1083

页数：3

共 27 条

[1]

STRUCTURE AND REACTIONS OF CLOSED DUPLEX DNA [J].