SITES AND EFFICACY OF PHOTODAMAGE BY TIN ETIOPURPURIN INVITRO USING DIFFERENT DELIVERY SYSTEMS

被引：51

作者：

KESSEL, D ^{[1
]}

MORGAN, A ^{[1
]}

GARBO, GM ^{[1
]}

机构：

[1] UNIV TOLEDO,DEPT CHEM,TOLEDO,OH 43606

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1991年 / 54卷 / 02期

关键词：

D O I：

10.1111/j.1751-1097.1991.tb02006.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Photosensitization by tin etiopurpurin (SnET2) was determined in cell culture using sensitizer dissolved in ethanol or solubilized via three different delivery systems: Cremophor EL, gamma-cyclodextrin or Molecusol (a more water-soluble cyclodextrin derivative). Sensitizer uptake was substantially more efficient when the delivery systems were employed, in terms of intracellular level needed to lethally photosensitize cells. We observed photodamage at both membrane and mitochondrial loci, but the former was better correlated with loss of viability.

引用

页码：193 / 196

页数：4

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