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NUCLEOLYSIS OF THE RABBIT INTERVERTEBRAL-DISK USING CHONDROITINASE ABC
被引：15
作者：
HENDERSON, N
STANESCU, V
CAUCHOIX, J
机构：
来源：
关键词：
D O I：
10.1097/00007632-199102000-00020
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The nucleolytic action of chondroitinase ABC was studied by the use of rabbit lumbar intervertebral discs. The injection of one unit of enzyme results in necrosis of the nucleus pulposus. Radiologic, histologic, and biochemical changes were evident in discs studied 2 days after injection, and consistent nucleolysis was seen in those studied after 6 days. These results show that chondroitinase ABC deserves further evaluation as a possible chemonucleolytic enzyme.
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页码：203 / 208
页数：6
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