SWR MICE ARE RESISTANT TO COLLAGEN-INDUCED ARTHRITIS BUT PRODUCE POTENTIALLY ARTHRITOGENIC ANTIBODIES

被引：31

作者：

REIFE, RA ^{[1
]}

LOUTIS, N ^{[1
]}

WATSON, WC ^{[1
]}

HASTY, KA ^{[1
]}

STUART, JM ^{[1
]}

机构：

[1] UNIV TENNESSEE, CTR HLTH SCI, DEPT MED, MEMPHIS, TN 38163 USA

来源：

ARTHRITIS AND RHEUMATISM | 1991年 / 34卷 / 06期

关键词：

D O I：

10.1002/art.1780340621

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

SWR mice are resistant to collagen-induced arthritis but produce antibodies to type II collagen. To determine if these antibodies have arthritogenic potential, serum from collagen-immunized mice was concentrated and passively transferred to DBA/1 mice. The recipients developed severe arthritis within 72 hours. To evaluate the role of complement, SWR mice were bred with congenic inbred B10.D2/oSn (complement deficient) and B10.D2/nSn (complement normal) mice. Collagen-immunized (SWR x B10.D2/nSn)F1 mice had high levels of C5 and were susceptible to arthritis, while (SWR x B10.D2/oSn)F1 mice were deficient in C5 and were resistant to arthritis.

引用

页码：776 / 781

页数：6

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