REVERSAL OF THE ANTIVIRAL ACTIVITY OF RIBAVIRIN AGAINST SINDBIS VIRUS IN AE ALBOPICTUS MOSQUITO CELLS

被引：8

作者：

LIAO, HJ ^{[1
]}

STOLLAR, V ^{[1
]}

机构：

[1] UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT MOLEC GENET & MICROBIOL,PISCATAWAY,NJ 08854

来源：

ANTIVIRAL RESEARCH | 1993年 / 22卷 / 04期

关键词：

SINDBIS VIRUS; AEDES-ALBOPICTUS MOSQUITO CELLS; RIBAVIRIN; GTP POOLS;

D O I：

10.1016/0166-3542(93)90038-K

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Earlier work in our laboratory has shown that the replication of Sindbis virus in Aedes albopictus mosquito cells is inhibited by ribavirin (Rbv) and mycophenolic acid (MPA) (Sarver and Stollar (1978) Virology 91, 267-282; Malinoski and Stollar (1980) Virology 102, 473-476). We report here that the antiviral effect of Rbv and MPA can be reversed by depriving infected cells of methionine or isoleucine, or by treating them with fluorodeoxyuridine (FUdR) or cycloleucine. We suggest that, as was the case when the antiviral activity of Rbv was reversed by actinomycin D (Malinoski and Stollar (1981a) Virology 110, 281-291), these effects may be mediated by changes in the GTP pools of treated cells.

引用

页码：285 / 294

页数：10

共 26 条

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