HEMOPHAGOCYTIC SYNDROME IN A PATIENT WITH RHEUMATOID-ARTHRITIS

被引：27

作者：

ONISHI, R

NAMIUCHI, S

机构：

[1] Department of Hematology and Immunology, Tazuke-Kofukai Medical Research Institute, Kitano Hospital, Kita-ku,, Osaka, 530, 13–3, Kamiyama-cho

[2] Department of Internal Medicine, Saisei-kai Noe Hospital, Osaka

来源：

INTERNAL MEDICINE | 1994年 / 33卷 / 10期

关键词：

EPSTEIN-BARR VIRUS; SYSTEMIC LUPUS ERYTHEMATOSUS;

D O I：

10.2169/internalmedicine.33.607

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

A 63-year-old female, who had been diagnosed with rheumatoid arthritis (RA) 3 years previously, was admitted due to progressive pancytopenia, lymphadenopathy, fever, and weight loss. The physical and laboratory findings fulfilled all of the American Rheumatism Association (ARA) revised criteria for RA. Her bone marrow aspirate revealed a decreased nuclear cell count (1.8x10(4)/mul) and megakaryocyte count (0/mul), and macrophages phagocytizing blood cells (4%), indicating the presence of hemophagocytic syndrome. The serological tests for several viruses revealed no obvious viral etiology. However, a slight Epstein-Barr virus (EBV) reactivation could not be excluded. Administration of 40 mg prednisolone daily improved her abnormal hematological findings and immunological laboratory parameters. This is a case of RA accompanied by hemophagocytic syndrome, which has not been reported previously as a complication of RA.

引用

页码：607 / 611

页数：5

共 27 条

[1]

Arnett F.C., Edworthy S.M., Bloch D.A., Et al., The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis, Arthritis Rheum, 31, (1988)

[2]

Richert-Boe K.E., Hematologic complications of rheumatic disease, Hematol/Oncol Clin North Am, 1, (1987)

[3]

Tan E.M., Cohen A.S., Fries J.F., Et al., The 1982 revised criteria for the classification of systemic lupus erythematosus, Arthritis Rheum, 25, (1982)

[4]

Michael S.R., Vural I.L., Bassen F.A., Schaefer L., The hematologic aspects of disseminated (systemic) lupus erythematosus, Blood, 6, (1951)

[5]

Arya S., Hong R., Gilbert E.F., Reactive hemophagocytic syndrome, Pediatr Pathol, 3, (1985)

[6]

Risdall R.J., McKenna R.W., Nesbitt M.E., Et al., Virus-associated hemophagocytic syndrome

[7]

a benign histiocytic proliferation distinct from malignant histiocytosis, Cancer, 44, (1979)

[8]

Barnes N., Bellamy D., Ireland R., Parsons V., Costello J., Pulmonary tuberculosis complicated by haemophagocytic syndrome and rifampicininduced tubulointerstitial nephritis, Br J Dis Chest, 78, (1984)

[9]

Gill K., Marrie T., Hemophagocytosis secondary to mycoplasma pneumonia infection, Am J Med, 82, (1987)

[10]

Manoharan A., Painter D., Histiocytic medullary reticulosis, Lancet, 2, (1982)

← 1 2 3 →