FACILE PREPARATION OF CARBAPENEM SYNTHONS VIA MICROWAVE-INDUCED RAPID REACTION

被引：52

作者：

BANIK, BK ^{[1
]}

MANHAS, MS ^{[1
]}

NEWAZ, SN ^{[1
]}

BOSE, AK ^{[1
]}

机构：

[1] STEVENS INST TECHNOL,DEPT CHEM & CHEM ENGN,HOBOKEN,NJ 07030

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(01)80956-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A simplified and stereocontrolled synthesis of alpha-vinyl and alpha-alkyl beta-lactams has been achieved in open vessels under microwave irradiation in unmodified domestic microwave ovens. These compounds - prepared in the course of a few minutes for each reaction step (including catalytic transfer hydrogenation) - are convenient synthons for various cis and trans carbapenems.

引用

页码：2363 / 2368

页数：6

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