KAPPA-OPIOID RECEPTOR-MEDIATED REGULATION OF PROLACTIN AND ALPHA-MELANOCYTE-STIMULATING HORMONE-SECRETION IN MALE AND FEMALE RATS

被引：9

作者：

MANZANARES, J

WAGNER, EJ

MOORE, KE

LOOKINGLAND, KJ

机构：

[1] Department of Pharmacology, Toxicology Michigan State University East Lansing

来源：

LIFE SCIENCES | 1993年 / 53卷 / 10期

关键词：

D O I：

10.1016/0024-3205(93)90501-S

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The purpose of this study was to examine the effects of the kappa opioid receptor agonist U-50,488 and antagonist nor-binaltorphimine (NOR-BNI) on the secretion of prolactin and a-melanocyte-stimulating hormone (alphaMSH) in male and female rats. Activation of kappa opioid receptors with U-50,488 increased plasma prolactin concentrations in both male and female rats, whereas blockade of kappa opioid receptors with NOR-BNI decreased plasma prolactin concentrations in male, but not in female rats. U-50,488 also increased and NOR-BNI decreased plasma concentrations of alphaMSH; similar effects were observed in both male and female rats. These results reveal a sexual difference in kappa opioid receptor-mediated regulation of prolactin, but not alphaMSH secretion.

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收藏

页码：795 / 801

页数：7

相关论文

共 18 条

[1] NEUROENDOCRINE REGULATION OF PROLACTIN-RELEASE [J].

BENJONATHAN, N ;

ARBOGAST, LA ;

HYDE, JF .

PROGRESS IN NEUROBIOLOGY, 1989, 33 (5-6) :399-447

[2] DOPAMINE - A PROLACTIN-INHIBITING HORMONE [J].

BENJONATHAN, N .

ENDOCRINE REVIEWS, 1985, 6 (04) :564-589

[3] BIOCHEMICAL AND PHYSIOLOGICAL-STUDIES OF THE BETA-ADRENOCEPTOR AND THE D-2 DOPAMINE RECEPTOR IN THE INTERMEDIATE LOBE OF THE RAT PITUITARY-GLAND - A REVIEW [J].

COTE, TE ;

ESKAY, RL ;

FREY, EA ;

GREWE, CW ;

MUNEMURA, M ;

STOOF, JC ;

TSURUTA, K ;

KEBABIAN, JW .

NEUROENDOCRINOLOGY, 1982, 35 (03) :217-224

[4] A NEUROGENIC TIMING FACTOR IN CONTROL OF THE OVULATORY DISCHARGE OF LUTEINIZING HORMONE IN THE CYCLIC RAT [J].

EVERETT, JW ;

SAWYER, CH ;

MARKEE, JE .

ENDOCRINOLOGY, 1949, 44 (03) :234-250

[5] ACTIVATION OF OPIOID RECEPTORS IN THE MEDIOBASAL HYPOTHALAMUS STIMULATES PROLACTIN SECRETION IN THE CONSCIOUS RAT [J].

KAPOOR, R ;

WILLOUGHBY, JO .

JOURNAL OF NEUROENDOCRINOLOGY, 1990, 2 (03) :347-350

[6]

Konig JFR, 1963, RAT BRAIN STEREOTAXI

[7] OPIOID K-RECEPTORS AND THE SECRETION OF PROLACTIN (PRL) AND GROWTH-HORMONE (GH) IN THE RAT .1. EFFECTS OF OPIOID K-RECEPTOR AGONISTS BREMAZOCINE AND U-50,488 ON SECRETION OF PRL AND GH - COMPARISON WITH MORPHINE [J].

KRULICH, L ;

KOENIG, JI ;

CONWAY, S ;

MCCANN, SM ;

MAYFIELD, MA .

NEUROENDOCRINOLOGY, 1986, 42 (01) :75-81

[8] KAPPA-OPIOID-RECEPTOR-MEDIATED REGULATION OF ALPHA-MELANOCYTE-STIMULATING HORMONE-SECRETION AND TUBEROHYPOPHYSIAL DOPAMINERGIC NEURONAL-ACTIVITY [J].

MANZANARES, J ;

LOOKINGLAND, KJ ;

MOORE, KE .

NEUROENDOCRINOLOGY, 1990, 52 (02) :200-205

[9] SEXUAL DIFFERENCES IN THE ACTIVITY OF PERIVENTRICULAR-HYPOPHYSEAL DOPAMINERGIC-NEURONS IN RATS [J].

MANZANARES, J ;

TONEY, TW ;

EATON, MJ ;

MOORE, KE ;

LOOKINGLAND, KJ ;

TIAN, Y .

LIFE SCIENCES, 1992, 51 (13) :995-1001

[10] ACTIVATION OF TUBEROHYPOPHYSIAL DOPAMINE NEURONS FOLLOWING INTRACEREBROVENTRICULAR ADMINISTRATION OF THE SELECTIVE KAPPA-OPIOID RECEPTOR ANTAGONIST NOR-BINALTORPHIMINE [J].

MANZANARES, J ;

LOOKINGLAND, KJ ;

LAVIGNE, SD ;

MOORE, KE .

LIFE SCIENCES, 1991, 48 (12) :1143-1149