A NOVEL BREATH-ACTUATED DEVICE (AUTOHALER(TM)) CONSISTENTLY ACTUATES DURING THE EARLY PHASE OF INSPIRATION

被引：12

作者：

MARSHIK, PL ^{[1
]}

LARSEN, JS ^{[1
]}

LEACH, CL ^{[1
]}

HALVERSON, PC ^{[1
]}

EKHOLM, BP ^{[1
]}

AMIES, MH ^{[1
]}

KAISER, HB ^{[1
]}

WEISBERG, SC ^{[1
]}

SELLERS, JA ^{[1
]}

机构：

[1] ALLERGY & ASTHMA SPECIALISTS PA,MINNEAPOLIS,MN 55402

来源：

JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG | 1995年 / 8卷 / 02期

关键词：

METERED DOSE INHALER; INSPIRATORY TIME; BREATH ACTUATED DEVICE; CONSISTENCY;

D O I：

10.1089/jam.1995.8.187

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Objective To establish and quantify the point during inspiration that the Autohaler((TM)) (AH) inhalation system releases a metered dose of aerosol (placebo). The sound objective was to determine if the Autohaler system actuates consistently, regardless of the canister life. Design Double-blind, randomized, two-period crossover, one-day trial. Setting Community based allergy and asthma clinic. Participants Twelve patients with mild to moderate asthma. Results Mean verbal training time for the AH which included the patient demonstrating their ability to correctly use the AH was approximately 6 minutes. The mean time for actuation for the AH early in its canister life(''new canister'') was 195 msec compared to 205 msec for the AH late in its canister life (''old canister'') (p=0.589). This represented the early part of inspiration as patients had a mean inspiratory duration of 2231 msec for the ''new'' AH and 2343 msec for the ''old'' AH. The mean percentage of inspiration time required to actuate the ''new'' AH was 8.92% compared to 8.82% for the ''old'' AH. Patients rated the system as easier to much easier to use compared with their current standard press and breathe inhaler. Conclusions The AH consistently actuates early during inspiration, which is considered the optimal time for drug delivery, regardless of the canister life.

引用

页码：187 / 195

页数：9

共 10 条

[1]

Larsen J.S., Hahn M., Kochevar J.W., Morris R.J., Kaiser H.B., Weisberg S.C., Halverson P.C., Quessey S.N., Administration errors with a conventional metered dose inhaler versus a novel breath actuated device, Ann All, 71, pp. 103-106, (1993)

[2]

Hanania N.A., Wiltman R., Kesten S., Chapman K.R., Medical Personnel's Knowledge of and Ability to use Inhaling Devices, Chest, 105, 1, pp. 111-116, (1994)

[3]

Epstein S.E., Manning C.P., Ashley M.J., Corey P.N., Survey of the clinical use of pressurized aerosol inhalers, Can Med Assoc J, 120, 7, pp. 813-816, (1979)

[4]

Shim C., Williams M.H., The adequacy of inhalation of aerosol from canister nebulizers, Am J Med, 69, pp. 891-894, (1980)

[5]

Chapman K.R., Love L., Brubaker H., A Comparison of breath-actuated and conventional metered-dose inhaler inhalation techniques in elderly subjects, Chest, 104, pp. 1332-1337, (1993)

[6]

SAS Institute Inc., (1989)

[7]

Orehek J., Gayrard P., Grimaud, Charpin C.H., Patient error in use of bronchodilator metered aerosols, Br Med, J 1, (1976)

[8]

Newman S.P., Pavia D., Clarks S.W., Improving the bronchial deposition of pressurized aerosols, Chest Supplement, 80, 6, pp. 909-911, (1981)

[9]

Riley D.L., Liu R.T., Edelman N.H., Enhanced Responses to Aerosolized Bronchodilator Therapy in Asthma Using Respiratory Maneuvers, Chest, 76, 5, pp. 501-507, (1979)

[10]

Riley D.L., Weitz B.W., Edelman N.H., The Responses of Asthmatic Subjects to Isoproterenol Inhaled at Differing Lung Volumes, Am Rev Resp Dis, 114, pp. 509-515, (1976)

← 1 →