EXPRESSION OF A HYDROPHILIC SURFACE PROTEIN IN INFECTIVE STAGES OF LEISHMANIA-MAJOR

被引:63
作者
FLINN, HM [1 ]
RANGARAJAN, D [1 ]
SMITH, DF [1 ]
机构
[1] UNIV LONDON IMPERIAL COLL SCI & TECHNOL,DEPT BIOCHEM,LONDON SW7 2AZ,ENGLAND
基金
英国惠康基金;
关键词
LEISHMANIA; METACYCLIC; STAGE-SPECIFIC GENE EXPRESSION; AMINO ACID REPEAT; LIPOPHOSPHOGLYCAN;
D O I
10.1016/0166-6851(94)90077-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A family of differentially expressed genes from Leishmania major contains one sequence (Gene B) that encodes a novel, hydrophilic protein found on the surface of infective parasite stages. The 177-residue, acidic Gene B protein is characterised by an amino acid repetitive element, comprising 45% of the total molecule, that is related to the cell-wall binding domain of protein A from Staphylococcus aureus. No identifiable signal peptide, membrane-spanning domain or consensus for glycosylphosphatidylinositol anchor attachment to the cell surface is found elsewhere in the deduced protein sequence. In vitro, the Gene B protein fractionates with the parasite cell surface glycoconjugates, lipophosphoglycan and the glycoinositolphospholipids. This protein is the first characterised surface peptide marker for infective stages of the Leishmania life cycle.
引用
收藏
页码:259 / 270
页数:12
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