EFFECT OF PINDOLOL ON THE PROLACTIN RESPONSE TO D-FENFLURAMINE

被引：40

作者：

PARK, SBG ^{[1
]}

COWEN, PJ ^{[1
]}

机构：

[1] UNIV OXFORD,LITTLEMORE HOSP,DEPT PSYCHIAT,PSYCHOPHARMACOL RES UNIT,OXFORD OX4 4XN,ENGLAND

来源：

PSYCHOPHARMACOLOGY | 1995年 / 118卷 / 04期

基金：

英国惠康基金;

关键词：

D-FENFLURAMINE; 5-HT RECEPTORS; PROLACTIN; NEUROENDOCRINE;

D O I：

10.1007/BF02245948

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied the effect of the 5-HT1A receptor antagonist, pindolol, on the prolactin (PRL) response to the 5-HT releasing agent, d-fenfluramine (cl-FEN), in ten healthy male volunteers. Pindolol pretreatment lowered baseline PRL levels but, when this effect was taken into account, did not significantly attenuate the PRL response to d-FEN. Within the limitations that attend the use of pindolol as a 5-HT1A receptor antagonist, the data suggest that although 5-HT1A receptors may play a role in the tonic release of PRL, they are not involved in the release of PRL produced by d-FEN. We propose that the PRL response to d-FEN may involve selective activation of postsynaptic 5-HT2 receptors.

引用

页码：471 / 474

页数：4

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