PHOTO-CHEMICAL REACTIONS OF CHLORPROMAZINE - CHEMICAL AND BIOCHEMICAL IMPLICATIONS

被引：62

作者：

ROSENTHAL, I ^{[1
]}

BENHUR, E ^{[1
]}

PRAGER, A ^{[1
]}

RIKLIS, E ^{[1
]}

机构：

[1] ISRAEL ATOM ENERGY COMMISSION,NUCL RES CTR NEGEV,BEER SHEVA,ISRAEL

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1978年 / 28卷 / 4-5期

关键词：

D O I：

10.1111/j.1751-1097.1978.tb06975.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract— The photoexcited chlorpromazine reacts with methanol to yield promazine and 2‐methoxypromazine by two different reaction pathways: hydrogen atom abstraction and nucleophilic attack. respectively. When the photoexcitation of chlorpromazine is performed in the presence of protein or nucleic acids, chlorpromazine binds to the biopolymer. This binding is drastically pH‐dependent and correlates to the phototoxic effect exhibited in chlorpromazine—photosensitization of E. coli. No photodynamic damage of E. coli attributed to CPZ‐sensitization of molecular oxygen could be detected. Copyright © 1978, Wiley Blackwell. All rights reserved

引用

页码：591 / 594

页数：4

共 16 条

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