GROWTH-HORMONE RECEPTORS IN HYPOTHALAMIC AND EXTRA-HYPOTHALAMIC TISSUES

被引：39

作者：

FRASER, RA ^{[1
]}

ATTARDO, D ^{[1
]}

HARVEY, S ^{[1
]}

机构：

[1] UNIV ALBERTA, DEPT PHYSIOL, EDMONTON T6G 2H7, ALBERTA, CANADA

来源：

JOURNAL OF MOLECULAR ENDOCRINOLOGY | 1990年 / 5卷 / 03期

关键词：

D O I：

10.1677/jme.0.0050231

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Central GH receptors (GHR) have been identified in hypothalamic and extra-hypothalamic tissues of rabbit and chicken brains. Plasma membranes of the rabbit brain demonstrated specific saturable high-affinity, low-capacity binding sites for I-125-labelled GH. RNA extracted from hypothalamic and extra-hypothalamic tissues of rabbit and chicken brains contained mRNA that hybridized with a cDNA probe for the rabbit liver GHR. This transcript was of a similar size to the major GHR mRNA moiety in rabbit liver. The expression of these moieties was age related, and higher in adult than in neonatal animals.

引用

页码：231 / 238

页数：8

共 44 条

[1] HUMAN GROWTH-HORMONE AND SOMATOMEDIN-C SUPPRESS THE SPONTANEOUS RELEASE OF GROWTH-HORMONE IN UNANESTHETIZED RATS [J].

ABE, H ;

MOLITCH, ME ;

VANWYK, JJ ;

UNDERWOOD, LE .

ENDOCRINOLOGY, 1983, 113 (04) :1319-1324

[2] ACTIVATION OF GROWTH-HORMONE SHORT LOOP NEGATIVE FEEDBACK DELAYS PUBERTY IN THE FEMALE RAT [J].

ADVIS, JP ;

WHITE, SS ;

OJEDA, SR .

ENDOCRINOLOGY, 1981, 108 (04) :1343-1352

[3] GROWTH HORMONE-BINDING SITES IN CHICKEN HYPOTHALAMUS [J].

ATTARDO, D ;

HARVEY, S .

JOURNAL OF MOLECULAR ENDOCRINOLOGY, 1990, 4 (01) :23-29

[4] STUDIES ON THE ACCESSIBILITY OF PROLACTIN AND GROWTH-HORMONE TO BRAIN - EFFECT OF OPIATE AGONISTS ON HORMONE LEVELS IN SERIAL, SIMULTANEOUS PLASMA AND CEREBROSPINAL-FLUID SAMPLES IN THE RHESUS-MONKEY [J].

BELCHETZ, PE ;

RIDLEY, RM ;

BAKER, HF .

BRAIN RESEARCH, 1982, 239 (01) :310-314

[5]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

[6] INTRAVENTRICULARLY INJECTED GROWTH-HORMONE STIMULATES SOMATOSTATIN RELEASE INTO RAT HYPOPHYSEAL PORTAL BLOOD [J].

CHIHARA, K ;

MINAMITANI, N ;

KAJI, H ;

ARIMURA, A ;

FUJITA, T .

ENDOCRINOLOGY, 1981, 109 (06) :2279-2281

[7] BINDING-STUDIES WITH INTACT RAT PROLACTIN AND A 16K FRAGMENT OF THE HORMONE [J].

CLAPP, C ;

SEARS, PS ;

NICOLL, CS .

ENDOCRINOLOGY, 1989, 125 (02) :1054-1059

[8] GROWTH-HORMONE (GH) SECRETION IN THE CONSCIOUS RAT - NEGATIVE FEEDBACK OF GH ON ITS OWN RELEASE [J].

CLARK, RG ;

CARLSSON, LMS ;

ROBINSON, ICAF .

JOURNAL OF ENDOCRINOLOGY, 1988, 119 (02) :201-209

[9] ON THE MECHANISM OF GROWTH-HORMONE AUTOFEEDBACK REGULATION - POSSIBLE ROLE OF SOMATOSTATIN AND GROWTH HORMONE-RELEASING FACTOR [J].

CONWAY, S ;

MCCANN, SM ;

KRULICH, L .

ENDOCRINOLOGY, 1985, 117 (06) :2284-2291

[10] CHANGES IN PROLACTIN BINDING-SITES IN THE RABBIT HYPOTHALAMUS INDUCED BY PHYSIOLOGICAL AND PHARMACOLOGICAL VARIATIONS OF PROLACTIN SERUM LEVELS [J].

DICARLO, R ;

MUCCIOLI, G .

BRAIN RESEARCH, 1981, 230 (1-2) :445-450

← 1 2 3 4 5 →