MIXING AND DEMIXING OF MICRODOSE QUANTITIES OF SODIUM-SALICYLATE IN A DIRECT COMPRESSION VEHICLE

被引：26

作者：

BRYAN, L

RUNGVEJHAVUTTIVITTAYA, Y

STEWART, PJ

机构：

[1] Department of Pharmacy, University of Queensland, St. Lucia

来源：

POWDER TECHNOLOGY | 1979年 / 22卷 / 02期

关键词：

D O I：

10.1016/0032-5910(79)80020-0

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The rate and degree of mixing of microdose quantities of sodium salicylate with a direct compression vehicle was similar for both ordered and random mechanisms of mixing. However, the random mix, in contrast to the ordered mix, showed significant segregation under demixing conditions. A study of the effect of sodium salicylate concentrations on ordered mixing homogeneity demonstrated that concentrations which oversaturated the surface adsorption sites on the direct compression vehicle resulted in unsatisfactory mixes with a high degree of non-uniformity. © 1979.

引用

页码：147 / 151

页数：5

共 15 条

[1]

CLARKE EGS, 1969, EXTRA PHARMACOPOEIA, P806

[2] POWDER MIXING IN TABLETING OF FENFLURAMINE HYDROCHLORIDE - EVALUATION OF A MIXER [J].