SODIUM LOADING TREATMENT FOR AMPHOTERICIN B-INDUCED NEPHROTOXICITY

被引：19

作者：

GARDNER, ML ^{[1
]}

GODLEY, PJ ^{[1
]}

WASAN, SM ^{[1
]}

机构：

[1] UNIV TEXAS, COLL PHARM, ROOM 5110, AUSTIN, TX 78712 USA

来源：

DICP-THE ANNALS OF PHARMACOTHERAPY | 1990年 / 24卷 / 10期

关键词：

D O I：

10.1177/106002809002401006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The increased frequency and duration of antifungal treatment with amphotericin B in immunocompromised patients has stimulated a great deal of research into the mechanisms of its nephrotoxic effects and treatment modalities designed to attenuate these effects. A review of amphotericin B-induced nephrotoxicity, the underlying pathophysiologic mechanisms, and the role of salt loading as a means of minimizing renal impairment are described. Both animal and human studies regarding the efficacy of sodium loading are presented as well as a case report describing the use of salt supplementation over a prolonged course of therapy.

引用

页码：940 / 946

页数：7

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