THYROTROPIN RELEASING HORMONE STIMULATES RELEASE OF [DOPAMINE-H-3 FROM SLICES OF RAT NUCLEUS ACCUMBENS INVITRO

被引：96

作者：

KERWIN, RW

PYCOCK, CJ

机构：

[1] Department of Pharmacology, Medical School, University of Bristol, Bristol

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1979年 / 67卷 / 03期

关键词：

D O I：

10.1111/j.1476-5381.1979.tb08682.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Thyrotrophin releasing hormone (TRH) (25 to 100 μm) was found to stimulate the efflux of [3H]‐dopamine from small slices of rat nucleus accumbens, but not from similar slices of rat caudate nucleus. Uptake inhibition was not responsible for this action, since at 10 and 50 μm TRH had no effect on the ability of small slices of nucleus accumbens to accumulate radioactivity when incubated with 10−7 m [3H]‐dopamine. In addition the hormone had no effect on basal or dopamine‐stimulated adenylate cyclase, nor did it displace [3H]‐spiperone binding, in membrane preparations from nucleus accumbens. 1979 British Pharmacological Society

引用

页码：323 / 325

页数：3

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