BLOODLESS TESTING FOR MICROPOROUS MEMBRANE-OXYGENATOR FAILURE - A PRELIMINARY-STUDY

被引:13
作者
TAMARI, Y [1 ]
TORTOLANI, AJ [1 ]
LEESENSIBA, KJ [1 ]
机构
[1] CORNELL UNIV,MED CTR,COLL MED,DEPT SURG,NEW YORK,NY 10021
关键词
OXYGENATOR; MEMBRANE; MICROPOROUS; FAILURE; PLASMA LEAKAGE; PRESSURE; ALBUMIN;
D O I
10.1177/039139889101400307
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The use of a bloodless solution and high pressure to accelerate microporous membrane oxygenator (MMO) failure was investigated. It was hypothesized that albumin acts as a wetting agent, contributing to plasma leakage through the membrane, and that high MMO outlet pressure accelerates the process. Three MMO, B-Bentley BCM-40 (n = 7), M - Medtronic Maxima (n = 4), and S - Sarns 16310 (n = 7) were tested at 37 +/- 2-degrees-C using three identical closed recirculating circuits and four conditions: 1) Lactated Ringer solution (LR) with MMO outlet pressure (Pmo) 750 mmHg; 2) LR + albumin (4 g/100 ml), Pmo 150 mmHg; 3) LR + albumin, Pmo 300 mmHg; and 4) LR + albumin, Pmo 750 mmHg. "Blood" flow and gas flow were maintained at 2 l/min. Failure was indicated when Na+ was detected in the effluent of the MMO exhaust gas. There were no failures without albumin in the solution. B and M showed no signs of failure under any of the test conditions at 78 hours. S failed at (mean +/- SEM) 4.9 +/- 1.0, 12.1 +/- 0.2, and 19 hours for conditions 4, 3, and 2 respectively. Preceding failure, inlet gas pressure increased more than eightfold (27 +/- 1 to 224 +/- 34 mmH2O). These preliminary results are similar to previous findings with blood and suggest that high MMO outlet pressure and the presence of albumin may promote plasma breakthrough for S. The combination may provide a basis for an accelerated bloodless test for MMO compatibility with long-term respiratory support.
引用
收藏
页码:154 / 160
页数:7
相关论文
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