STUDY OF CHEMICAL CARCINOGENESIS .18. ALPHA-HYDROXYLATION OF N-NITROSOPYRROLIDINE AND N'-NITROSONORNICOTINE BY HUMAN-LIVER MICROSOMES

被引：33

作者：

HECHT, SS ^{[1
]}

CHEN, CHB ^{[1
]}

MCCOY, GD ^{[1
]}

HOFFMANN, D ^{[1
]}

DOMELLOF, L ^{[1
]}

机构：

[1] UMEA UNIV,DEPT SURG,S-90185 UMEA,SWEDEN

来源：

CANCER LETTERS | 1979年 / 8卷 / 01期

关键词：

D O I：

10.1016/0304-3835(79)90020-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The environmental carcinogens N-nitrosopyrrolidine (NPYR) and N′-nitrosonornicotine (NNN) were incubated with human liver microsomes to test for the presence of enzymes catalyzing α-hydroxylation, which is likely to be an activation mechanism for these compounds. Both nitrosamines underwent α-hydroxylation; rates were higher for NPYR than for NNN, as observed in rats. The results indicate that both NPYR and NNN can be metabolically activated by human liver microsomes. © 1979.

引用

页码：35 / 41

页数：7

共 29 条

[1]

AUTRUP H, 1978, P SOC EXP BIOL MED, V159, P111

[2]

BALDWIN JE, 1976, TETRAHEDRON LETT, P333

[3] INDUCTION OF PULMONARY TUMOURS IN MICE BY NITROSONORNICOTINE POSIBLE CONSTITUENT OF TOBACCO SMOKE [J].

BOYLAND, E ;

ROE, FJC ;

GORROD, JW .

NATURE, 1964, 202 (493) :1126-&

[4]

BRUNNEMANN KD, 1977, CANCER RES, V37, P3218

[5]

CHEN CB, 1978, CANCER RES, V38, P3812

[6]

CHEN CB, 1978, CANCER RES, V38, P3639

[7] ORGANOTROPE CARCINOGENE WIRKUNGEN BEI 65 VERSCHIEDENEN N-NITROSO-VERBINDUNGEN AN BD-RATTEN [J].

DRUCKREY, H ;

PREUSSMA.R ;

IVANKOVI.S ;

SCHMAHL, D ;

AFKHAM, J ;

BLUM, G ;

MENNEL, HD ;

MULLER, M ;

PETROPOU.P ;

SCHNEIDE.H .

ZEITSCHRIFT FUR KREBSFORSCHUNG, 1967, 69 (02) :103-&

[8]

EISENBRAND G, 1978, INT AGENCY RES CANCE, V19, P311

[9]

FINE DH, 1978, IARC SCI PUBL, V19, P267

[10]

GOUGH TA, 1978, IARC SCI PUBL, V19, P297

← 1 2 3 →