SYNTHESIS OF ACID-LABILE GEMINAL BISPHOSPHONIC AND TRISPHOSPHONIC ACIDS

被引：10

作者：

GROSS, H ^{[1
]}

KEITEL, I ^{[1
]}

COSTISELLA, B ^{[1
]}

MCKENNA, CE ^{[1
]}

机构：

[1] UNIV SO CALIF,DEPT CHEM,LOS ANGELES,CA 90089

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1991年 / 61卷 / 3-4期

基金：

美国国家卫生研究院;

关键词：

7-PHOSPHONO-QUINONEMETHIDE SALTS; ARYLMETHANE TRISPHOSPHONATE; BROMOTRIMETHYLSILANE; SILYLDEALKYLATION; C-13; NA-23; P-31 NMR DATA;

D O I：

10.1080/10426509108036796

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Sodium salts (7, 8 respectively) of the unsaturated bisphosphonic acid 5 (2, 6-di-tert-butyl-7, 7-bis(phosphono)-1, 4-benzoquinone-4-methide) and the trisphosphonic acid 6 (4-hydroxy-3, 5-di-tert-butylphenylmethane tris(phosphonic acid), were prepared by buffered hydrolysis of the corresponding trimethylsilyl esters. The structures of 7 and 8 were determined by 13C and 31P NMR analysis. Compound 8 is the first well-established example of a gem trisphosphonic acid salt. © 1991, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：177 / 181

页数：5

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