HUMAN SERUM CATALASE DECREASES ENDOTHELIAL-CELL INJURY FROM HYDROGEN-PEROXIDE

被引：30

作者：

LEFF, JA ^{[1
]}

OPPEGARD, MA ^{[1
]}

TERADA, LS ^{[1
]}

MCCARTY, EC ^{[1
]}

REPINE, JE ^{[1
]}

机构：

[1] UNIV COLORADO,HLTH SCI CTR,DEPT MED,DENVER,CO 80262

来源：

JOURNAL OF APPLIED PHYSIOLOGY | 1991年 / 71卷 / 05期

关键词：

ANTIOXIDANTS; OXYGEN RADICALS; PEROXIDE; VASCULAR INJURY;

D O I：

10.1152/jappl.1991.71.5.1903

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Serum from normal human subjects contained variable amounts of catalase activity, which was inhibitable by heat, azide, trichloroacetic acid (TCA), or aminotriazole treatment. Serum also decreased hydrogen peroxide (H2O2) concentrations in vitro and H2O2-mediated injury to cultured endothelial cells. By comparison, heat-, azide-, TCA-, or aminotriazole-treated serum neither decreased H2O2 concentrations in vitro nor reduced H2O2-mediated damage to endothelial cells. We conclude that serum catalase activity can alter H2O2-dependent reactions. We speculate that variations in serum catalase activity may alter individual susceptibility to oxidant-mediated vascular disease or be a factor when added to test systems in vitro.

引用

页码：1903 / 1906

页数：4

共 20 条

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