PREFERENTIAL SMALL ARTERIOLAR VASODILATATION BY THE POTASSIUM CHANNEL OPENER, BRL-38227, IN CONSCIOUS SPONTANEOUSLY HYPERTENSIVE RATS

被引：13

作者：

BOUDIER, HAJS

MESSING, MWJ

VANESSEN, H

机构：

[1] Department of Pharmacology, Cardiovascular Research Institute Maastricht (CARIM), University of Limburg, 6200 MD Maastricht

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 218卷 / 01期

关键词：

BRL-38227; POTASSIUM CHANNEL OPENERS; MICROCIRCULATION; SPONTANEOUSLY HYPERTENSIVE RAT (SHR);

D O I：

10.1016/0014-2999(92)90166-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The microvascular effects of the potassium channel opener, BRL 38227 (the active enantiomer of cromakalim), were investigated in conscious spontaneously hypertensive rats (SHR) provided with a chronic dorsal microcirculatory chamber. BRL 38227 decreased blood pressure and increased heart rate in a dose-dependent manner. It dilated arterioles of different sizes, with the most pronounced effect on the smallest precapillary arterioles. Venule diameters were not significantly affected by BRL 38227. The data show a preferential sensitivity of small precapillary arterioles for potassium channel opening.

引用

页码：191 / 193

页数：3

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