SYNTHESIS OF NOVEL, HIGHLY POTENT CYCLIC HEXAPEPTIDE ANALOGS OF SOMATOSTATIN - POTENTIAL APPLICATION OF ORTHOGONAL PROTECTION FOR AFFINITY-CHROMATOGRAPHY

被引：8

作者：

SPANEVELLO, RA

HIRSCHMANN, R

RAYNOR, K

REISINE, T

NUTT, RF

机构：

[1] UNIV PENN,DEPT CHEM,PHILADELPHIA,PA 19104

[2] UNIV PENN,DEPT PHARMACOL,PHILADELPHIA,PA 19104

[3] MERCK SHARP & DOHME LTD,W POINT,PA 19486

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 36期

关键词：

D O I：

10.1016/S0040-4039(00)92279-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The syntheses of new cyclic hexapeptides are described. These peptides potently displace [I-125] CGP-23996 (des-Ala1, Gly2-desamino-Cys3[Tyr11]-dicarba3,14 SRIF) from SRIF receptors on AtT-20 cells. Two of these compounds are of potential value for the isolation of SRIF receptors by affinity chromatography. A key feature in the design was the use of orthogonal protection to provide selective covalent bonding to the solid support.

引用

页码：4675 / 4678

页数：4

共 21 条

[1]

Bodanszky M, 1984, PRACTICE PEPTIDE SYN, P24

[2]

BOSSHARD HR, 1973, HELV CHIM ACTA, V56, P717

[3] LARGE-SCALE SYNTHESIS OF A CYCLIC HEXAPEPTIDE ANALOG OF SOMATOSTATIN [J].