INDUCTION OF APOPTOTIC CELL-DNA FRAGMENTATION IN HUMAN-CELLS AFTER TREATMENT WITH HYPERTHERMIA

被引：48

作者：

FAIRBAIRN, JJ ^{[1
]}

KHAN, MW ^{[1
]}

WARD, KJ ^{[1
]}

LOVERIDGE, BW ^{[1
]}

FAIRBAIRN, DW ^{[1
]}

ONEILL, KL ^{[1
]}

机构：

[1] BRIGHAM YOUNG UNIV,DEPT MICROBIOL,PROVO,UT 84602

来源：

CANCER LETTERS | 1995年 / 89卷 / 02期

关键词：

APOPTOSIS; HYPERTHERMIA; COMET ASSAY; DNA PRECIPITATION; NUCLEOSOMAL FRAGMENTATION;

D O I：

10.1016/0304-3835(94)03668-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The biological significance of apoptosis is becoming increasingly clear. Its relevance in tumor response to treatment as well as recent evidence for its important function as a regulating mechanism in tumorigenesis has also been demonstrated. One of the most prominent biological features of apoptosis is nucleosomal DNA fragmentation. In this communication, we present a study of DNA fragmentation in Raji cells which have been subjected to hyperthermia treatment to induce apoptosis. We found that the induction and onset of fragmentation is swift, and consistent with previous reports that fragmentation must be a rapid event.

引用

页码：183 / 188

页数：6

共 29 条

[1]

ARENDS MJ, 1990, AM J PATHOL, V136, P593

[2] ACTIVATION OF PROGRAMMED CELL-DEATH (APOPTOSIS) BY CISPLATIN, OTHER ANTICANCER DRUGS, TOXINS AND HYPERTHERMIA [J].