A PRACTICAL SYNTHESIS OF THE 5-CHLOROMETHYL-FURO[2,3-B]PYRIDINE PHARMACOPHORE

被引:49
作者
CHOI, WB
HOUPIS, IN
CHURCHILL, HRO
MOLINA, A
LYNCH, JE
VOLANTE, RP
REIDER, PJ
KING, AO
机构
[1] Process Research, Merck Research Laboratories, Rahway, NJ 07065
关键词
D O I
10.1016/0040-4039(95)00850-C
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Synthesis of the furopyridine 2 was accomplished in 52% overall yield from 6-hydroxynicotinic acid (3). The synthesis is highlighted by a Heck coupling of 5 with ethylene followed by an NCS mediated oxidative cyclization and elimination sequence.
引用
收藏
页码:4571 / 4574
页数:4
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