EFFECTS OF PAPAVERINE ON GASTRIC EMPTYING AND GASTRIC SECRETION IN MAN

被引：6

作者：

BROMSTER, D

LINDGREN, E

ROSEN, A

THEORELL, M

机构：

[1] DEPARTMENT OF SURGERY, RADIOLOGY, SECTION OF CLINICAL PHARMACOLOGY, DEPARTMENT OF MEDICINE, SERAFIMERLASARETTET, STOCKHOLM

来源：

ACTA RADIOLOGICA-DIAGNOSIS | 1969年 / 8卷 / 04期

关键词：

D O I：

10.1177/028418516900800408

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The serum concentration of papaverine was studied after oral administration of 200 and 800 mg and after intravenous administration of 40 and 80 mg of the drug. No effect of the doses on the cholinergic mechanisms was observed. In studies with a test meal containing 1:{1 I, the oral doses resulted in an initially rapid and subsequently somewhat slower gastric emptying. These two effects could also be demonstrated in roentgen examinations using a barium contrast medium. The barium contrast became flocculent in all the subjects after administration of papaverine, supposedly due to a qualitative alteration of the gastric secretion produced by the drug. In vitro studies supported this hypothesis. © 1969, The Foundation Acta Radiologica. All rights reserved.

引用

页码：354 / &

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