ADENYLATE-CYCLASE FROM HUMAN DECIDUA PARIETALIS

被引:10
作者
WHITSETT, JA
JOHNSON, CL
机构
[1] CINCINNATI GEN HOSP,DEPT PHARMACOL & CELL BIOPHYS,CINCINNATI,OH 45229
[2] CHILDRENS HOSP,RES FDN,CINCINNATI,OH 45229
[3] CINCINNATI GEN HOSP,CROSLEY MEM NURSERY,CINCINNATI,OH 45229
关键词
D O I
10.1016/0002-9378(79)90280-1
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Adenylate cyclase (EC 4.6.1.1) activity was demonstrated in membrane fractions of human decidua parietalis. Adenylate cyclase activity was associated with membrane fractions of decidua but not chorion or amnion. Prostaglandins PGE1 and PGE2 but neither PGD2 nor PGF2α stimulated this activity at gestational ages 18 to 40 weeks. Fluoride and guanosine triphosphate stimulated decidual adenylate cyclase; however, epinephrine-stimulated adenylate cyclase activity was demonstrable only in the presence of guanosine triphosphate. The possible roles of adenylate cyclase activity in the decidua are discussed. © 1979.
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页码:479 / 483
页数:5
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