COROSSOLONE AND COROSSOLINE, 2 NEW CYTOTOXIC MONOTETRAHYDROFURAN GAMMA-LACTONES

被引：53

作者：

CORTES, D ^{[1
]}

MYINT, SH ^{[1
]}

LAURENS, A ^{[1
]}

HOCQUEMILLER, R ^{[1
]}

LEBOEUF, M ^{[1
]}

CAVE, A ^{[1
]}

机构：

[1] UNIV PARIS 11, FAC PHARM, CNRS, PHARMACOGNOSIE LAB, URA 496, F-92290 CHATENAY MALABRY, FRANCE

来源：

CANADIAN JOURNAL OF CHEMISTRY | 1991年 / 69卷 / 01期

关键词：

ANNONACEAE; ACETOGENINS; CYTOTOXICITY; SOURSOP; ANNONA-MURICATA;

D O I：

10.1139/v91-002

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The fractionation by solvents of the contents of the seeds of Annona muricata (Annonaceae), guided by the toxic activity towards the brine shrimp larva and the KB cancer cells, has enabled us to isolate two new cytotoxic mono-tetrahydrofuran gamma-lactones: corossolone 1 and corossolin 2. The structure of these two cytotoxic acetogenins was determined by analysis of the spectral data, NMR and MS in particular. The chemical correlation between 1 and 2 was established by the NaBH4 reduction of corossolone. 1 and 2 constitute the first examples of mono-tetrahydrofuran acetogenins with an unfunctionalized C-4.

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页码：8 / 11

页数：4

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